SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND CLOPIDOGREL BY SIMULTANEOUS EQUATION METHOD IN CAPSULE DOSAGE FORM
AbstractThe current work is intended towards the development of a simple, rapid and precise UV-Visible spectrophotometric method for the simultaneous estimation of Atorvastatin (ATR) and Clopidogrel (CP) present in the marketed formulation using UV simultaneous equation. Methanol was used as a solvent and the absorbance of the drug was measured at the absorbance maxima (λmax) of Atorvastatin & Clopidogrel, UV 246 nm & 202 nm respectively. Calibration curve plotted in concentration range 5-25 μg/mL exhibited an excellent linear relationship for both Atorvastatin and Clopidogrel. The method was found to comply all the validation parameters as per the ICH guideline, such as accuracy (mean recovery = 99.97%), precision, and linearity (r2 = 0.9934). The method showed good reproducibility and recovery with % RSD in the favorable range indicating the sensitivity of the method towards analyte. This method can be effectively employed for the day to day analysis of both drugs in the capsule dosage form.
Article Information
21
3305-3310
803
1100
English
IJPSR
T. S. Vishwas *, B. M. Gurupadayya, R. Maruthi and R. Jain
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
vishwasts27@gmail.com
12 October 2018
03 January 2019
03 January 2019
10.13040/IJPSR.0975-8232.10(7).3305-10
01 July 2019
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