SIMULTANEOUS EXPOSURE TO BENZENE AND ALCOHOL IN PETROL PUMP OPERATORSAbstract
A study on biological monitoring of simultaneous exposure to benzene and alcohol was made in petrol pump operators of Meerut city (India). In addition to alcohol, other confounding factors viz. cigarette smoke, food habit, age and work experience were also considered. Thirty two, 20-40 years old male workers were registered for this study. Respective urine samples collected after the workshift were analyzed for specific gravity, creatinine and phenol. Phenol concentration corrected to creatinine was found to be low (22.22 mg/g creatinine) in alcoholic pump operators in comparison to non-alcoholic operators (24.09 mg/g creatinine). It has been suggested that acute ethanol ingestion inhibits benzene oxidation in the liver with an ethanol inducible form of CYP450. Although urinary phenol concentration in the registered Indian petrol pump operators is less than BEI as suggested by ACGIH (50mg/g creatinine), simultaneous exposure to alcohol and benzene may potentiate the hepatotoxicity, cytotoxicity of benzene amongst petrol pump operators.
Yeshvandra Verma*, S.V.S. Rana and Narveer Singh
Toxicology laboratory, Department of Zoology, C.C.S. University, Meerut, Uttar Pradesh, India
04 January, 2016
16 April, 2016
08 May, 2016
01 June 2016