SIMULTANEOUS QUANTIFICATION OF OFLOXACIN AND ORNIDAZOLE IN COMBINED DRUG FORMULATION BY A SIMPLE ELECTRO-ANLYTICAL TECHNIQUEAbstract
In present study, a successful attempt has been made to develop a simple method for the simultaneous determination of ofloxacin and ornidazole using linear sweep Voltammetry (LSV) technique. Quantification of ofloxacin and ornidazole was done in Britton-Robinson Buffer of pH 5.5 using 0.1M KCl as a supporting electrolyte. Both ofloxacin and ornidazole exhibit reduction cathodic peak in given pH with peak potential at -1.30 V for ofloxacin and -0.42V for ornidazole vs. S.C.E. 0.1N HCl was used as Solvent for the analysis. The method was validated in the terms of its linearity, accuracy, precision, robustness, ruggedness, LOD and LOQ. Proposed method was found to be simple, precise, and accurate and can be successfully applied for routine quality control analysis and simultaneous determination of ofloxacin and ornidazole in combined drug formulations.
P. V. Rege * and P. A. Sathe
Department of Chemistry, Ramnarain Ruia College, Matunga (E), Mumbai-19, Maharashtra, India
18 April, 2011
21 June, 2011
29 July, 2011
01 August, 2011