SIMULTANEOUS QUANTIFICATION OF ROSUVASTATIN AND TELMISARTAN IN BULK AND TABLET – A VALIDATED UV-SPECTROPHOTOMETRIC TECHNIQUEAbstract
Rosuvastatin and Telmisartan are used together as a fixed dosage combination to treat hypertension associated with dyslipidemia. Objective: To develop and validate a simple, sensitive, precise, ecofriendly and cost-effective method for the determination of Rosu-vastatin and Telmisartan in bulk and pharmaceutical formulation as per ICH Guidelines. Methods: an effort has been made to develop a simple double beam UV Spectrophotometric method and validate the same with different parameters such as Linearity, Precision, Repeat-ability, Limit of Detection (LOD), Limit of Quantification (LOQ), Accuracy, Robustness, and Ruggedness. Results: Rosuvastatin and Telmisartanin Ethanol: Water 60: 40% v/v shows maximum absor-bance at 244 nm and 296 nm, respectively. Beer’s law was obeyed in the concentration range of 2-10µg/mL and 3-15µg/mL; The LOD and LOQ were found to 0.35µg/mL and 1.06 µg/ Rosuvastatin mL for Rosuvastatin and 0.54 µg/mL and 1.64 µg/mL for Telmisartan respectively. Recovery of Rosuvastatin and Telmisartan in tablet formulation was observed in the range of 80.00-120.00%. Conclusion: The proposed method is precise, accurate, eco-friendly and reproducible and can be used for routine analysis of Rosuvastatin and Telmisartan in bulk and pharmaceutical dosage form.
N. Patil and B. Sharannavar *
K. L. E. College of Pharmacy, Belagavi, K. L. E. Academy of Higher Education and Research, JNMC Campus, Belagavi, Karnataka, India.
03 April 2020
18 August 2020
05 September 2020
01 April 2021