SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF CIPROFLOXACIN AND ORNIDAZOLE IN TABLET DOSAGE FORMAbstract
Three simple sensitive, rapid, accurate and economical methods were developed for simultaneous estimation of Ciprofloxacin & Ornidazole in bulk and its pharmaceutical formulations. First method was based on the simultaneous equation, second method was based on Q-Analysis (Absorbance ratio method) and third method was based on multicomponent mode. The absorption maxima for Ciprofloxacin and Ornidazole were 272 nm and 319 nm in 0.1 N NaOH respectively. The iso-absorptive point for Ciprofloxacin Hydrochloride and Ornidazole was 292 nm. The calibration curve was linear over the concentration range 2.5 to 22.5 µg/ml of Ciprofloxacin & Ornidazole. The methods had been validated statistically and by recovery study. It can be used in the simultaneous estimation of Ciprofloxacin and Ornidazole in bulk drugs and its pharmaceutical preparations in a routine manner.
A.S. Grewal*, S.K. Patro , S.K. Kanungo and S.K. Bhardwaj
Assistant Professor, JCDM College of Pharmacy, Sirsa- 125 055, Haryana, India
24 April, 2012
14 May, 2012
21 July, 2012
01 August, 2012