SOLID DISPERSION – A PROMISING NOVEL APPROACH FOR IMPROVING THE SOLUBILITY OF POORLY SOLUBLE DRUGSAbstract
Solid dispersions is an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly soluble drugs. This article reviews the various types of solid dispersion, preparation techniques for solid dispersion and compiles some of the recent technologies. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization, along with nature of drugs in solid dispersions are also discussed. Finally, limited commercialization of solid dispersions and recent revival has been considered.
Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India
01 March, 2011
05 July, 2011
24 July, 2011
01 August, 2011