SOLID DISPERSION: OVERVIEW OF THE TECHNOLOGYAbstract
Up to 40% of new chemical entities (NCEs) discovered today by the pharmaceutical industry through combinatorial chemistry and high through put screening are highly lipophilic or poorly water soluble compounds, so the number of such compounds has dramatically increased and the solubility behaviour of these drugs has become one of the most challenging aspects in formulation development. So amongst the vast majority of strategies (like particle size reduction, use of surfactants, cosolvency, hydrotrophy etc) already reported in the literature to resolve this issue, solid dispersions have emerged as an advanced technique of improving the solubility/dissolution rate and hence, the bioavailability enhancement of a wide range of poorly water-soluble drugs. This review article mainly focuses on solubility ranges, biopharmaceutical classification system (BCS), list of poorly soluble drugs, commercial preparations, classification, types, advantages, limitations, methods of preparation and characterization of solid dispersions. In this review, besides above it is intended to discuss the recent advances and future prospects related to the solid dispersion technology.
K. Bashir Mir and N. Ahmed Khan*
Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India
03 December, 2016
27 January, 2017
16 May, 2017
01 June, 2017