SOLID DISPERSION: STRATEGIES TO ENHANCE SOLUBILITY AND DISSOLUTION RATE OF POORLY WATER-SOLUBLE DRUGAbstract
The solubility problem of drugs is always one of the most challenging aspects in formulation and development of dosage forms. In fact, most of new chemical entities are poorly water soluble and not well-absorbed after oral administration resulting in low bioavailability. The current challenges of the pharmaceutical industries are related to techniques that improve the water solubility of drugs. Solid dispersions are one of the most successful strategies to enhance the oral bioavailability of poorly water-soluble drugs by reducing particle size and improving drug wettability. This article reviews various types of solid dispersion, and their preparation techniques. Some of the practical aspects to be considered for the preparation of solid dispersions are selection of carrier and methods of physicochemical characterization thorough study of nature of drug in solid dispersion etc. are discussed. At the end of the article commercialization of some solid dispersion and recent revival has been considered. This article gives scope for research in enhancement of solubility of poorly water-soluble drugs.
N. M. Hande
Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Sec-08, CBD Belapur, Navi Mumbai, Maharashtra, India.
10 May 2023
17 August 2023
22 November 2023
01 February 2024