SOLID DISPERSION TECHNOLOGY: RECENT ADVANCEMENTS IN THE DELIVERY OF VARIOUS PHYTOCONSTITUENTSAbstract
Nature is an eminent source of potential therapeutic drugs, however; most of the herbal bioactives are left unexploited as precise remedies due to lack of appropriate formulation design and development. Pharmacological interventions of herbal molecules may often be limited due to insufficient solubility, bioavailability as well as instability aspects and it remains one of the most challenging facet for pharmaceutical scientists worldwide. Solid dispersion is one of the well established and convenient techniques for improving the oral absorption of drugs with poor aqueous solubility and dissolution rate. The objective of present study is to enlighten the role of solid dispersion approach for enhancement of solubility and bioavailability profile of various natural moieties. The manuscript also aims to summarize the important features of solid dispersions, carriers utilized, classification, preparation methods and characterization parameters. Numerous and significant research findings in the vistas of phytoconstitutents based solid dispersions are also discussed
Rakesh Pahwa , Umang Kataria , A. C. Rana , Rekha Rao and Sanju Nanda*
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India.
04 June, 2014
27 September, 2014
13 October, 2014
01 February, 2015