SOLID LIPID NANOPARTICLES: COLLOIDAL CARRIER SYSTEMS FOR DRUG DELIVERYAbstract
Solid lipid nanoparticles (SLN) are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids. They are introduced in 1990 as an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. They exhibit major advantages such as modulated release, improved bioavailability, protection of chemically labile molecules like retinol, peptides from degradation, cost effective excipients, improved drug incorporation and wide application spectrum. This paper presents an overview about the selection of the ingredients, different ways of SLN production, drug incorporation and release, characterization of SLN quality and structure, Sterilization, storage and stability of SLN dispersions and SLN applications.
G. Swathi, N. L. Prasanthi*, S. S. Manikiran and N. Ramarao
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India
12 July, 2010
07 October, 2010
10 November, 2010
01 December, 2010