SOLID SUPPORTED MICROWAVE ASSISTED RAPID SYNTHESIS OF 1, 3, 4 OXADIAZOLES
AbstractWe have carried out solid supported ,solvent free condition, microwave assisted rapid synthesis of 1- (2,5- substituted diphenyl)-1, 3, 4- oxadiazol -3(2H) – yl) ethanone (3a-3k) by cyclization of N’- (substituted phenyl methylidene) substituted benzohydrazide (2a-2k) in the presence of acetic anhydride and silica gel ( solid support) for 3-4 minutes by microwave irradiation giving excellent yield in short reaction time are notable advantages of this method. The structure elucidations of all the synthesized compounds have been accomplished by elemental analysis, IR, NMR and Mass spectroscopic method. The synthesized compounds (3a-3k) were screened in vitro for their antibacterial activities against S. aureus ( gram positive ) and E. coli ( gram negative ) by cup plate method . Some of the products of series were found to have quite good activities as compared to the standard drug streptomycin. The introduction of -F, -NO2, -Cl (electron withdrawing) group enhancing antibacterial activity
Article Information
52
2231-35
377
1347
English
IJPSR
Bhagyashri Lole, Shubhangi Waghmale and Pravina Piste *
P.G. Department of Chemistry, Yashavantrao Chavan Institute of Science Satara, (Mah.), India
ppiste321@gmail.com
21 December, 2015
27 January, 2016
13 February, 2016
10.13040/IJPSR.0975-8232.7(5).2231-35
01 May 2016
Download