SOLUBILITY ENHANCEMENT AND OPTIMIZATION OF VARIOUS VARIABLES OF FAST DISINTEGRATING TABLETS OF LERCANIDIPINE HYDROCHLORIDE USING CENTRAL COMPOSITE DESIGNAbstract
The oral route of drug administration is the most common and preferred method of delivery due to convenience and ease of ingestion, but it is problematic if the drug is poorly soluble. Sufficient drug absorption, reproducible bioavailability and pharmacokinetic profile of orally administered drug substances are highly dependent on the solubility of that compound in an aqueous medium. Also, the therapeutic effectiveness of drugs depends upon bioavailability and, ultimately, upon the solubility of drug molecules. Solid dispersions have attracted considerable interest as an efficient means of improving the solubility and hence bioavailability of a range of hydrophobic drugs. These systems are one of the most promising approaches for solubility enhancement. They are referred to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug (1-4). The aim of the present study was to improve the solubility and dissolution rate of Lercanidipine Hydrochloride (L) by formulating a solid dispersion with Polyvinyl pyrollidone (PVP-K30) and Guar gum. Central composite design (CCD) was employed using Design-Expert software version 12 to prepare optimized fast disintegrating tablets of Lercanidipine Hydrochloride.