SOLUBILITY ENHANCEMENT OF BCS CLASS II DRUGSAbstract
One of the major barriers in the development of oral dosage form is poor solubility. Poor water solubility obstructs drug bioavailability and decreases its pharmaceutical development. Many drugs are in the pipeline to enhance solubility to formulate dosage form to be taken by the most preferred route of administration that is the oral route. Etodolac is nonsteroidal anti-inflammatory drug having a wide spectrum of activities but belongs to BCS class II. The attempt has been made in this work to improve solubility by forming ternary inclusion complexes of Etodolac with PVP K30 and β-Cyclodextrins. The ternary inclusion complexes were prepared by the physical mixing method and kneading method. The prepared complexes were analyzed by different analytical techniques comprising differential scanning calorimetry, infrared spectroscopy and solubility study. Special emphasis was given on the solubility evaluation of drugs and complexes. Based on observations and results, one can easily conclude about the usefulness of the complexation technique for the enhancement of solubility.