SOLUBILITY ENHANCEMENT OF MELOXICAM BY LIQUISOLID TECHNIQUE AND ITS CHARACTERIZATIONAbstract
Solubility is the important parameter to design a dosage form; it is very difficult to formulate an insoluble drug in to final formulation. In This present study deals with the enhancement of solubility of poorly water soluble drug Meloxicam.: The liquisolid system is a novel technique for solubility enhancement and dissolution improvement of low soluble drugs. Liquisolid technique (powdered solution technology) is used to enhance the solubility parameter and dissolution rate of the drug. liquisolids were prepared by using non volatile solvents or hydrophobic carriers (like PEG 400, Tween 80, span 20) and their effect on dissolution of Meloxicam was studied. By using these solvents individually or in combination and find out the optimized formulation with good solubility.Based on the solubility studies the polyethylene glycol 400 (PEG400) is chosen as co solvent, Microcrystalline cellulose (MCC) used as carrier material and Aerosil used as coating material. In liquisolid system different nonvolatile or hydrophobic solvents are continuously added to the liquid until it convert in to a free flowing solid system Liquisolid system is characterized by flow properties, solubility studies in non volatile solvents (hydrophobic carriers), drug content, and in-vitro release evaluation. liquisolids of meloxicam with (2:1) polyethylene glycol 400,span 20 shows good solubility(F6). F6 is an optimized formulation.
A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam. Andhra Pradesh, India
18 June, 2014
28 August, 2014
15 November, 2014
01 February, 2015