SPANLASTICS: A MODERN APPROACH FOR NANOVESICULAR DRUG DELIVERY SYSTEMAbstract
Drug delivery to targeted sites is restricted by various barriers. The conventional drug delivery systems like tablets, capsules, suspensions, emulsions, elixirs, lotions etc. are being encountered with a number of issues such as poor bioavailability, drug shelf life, drug-excipients incompatibilities and patient in compliance. Thus with the advent of novel drug delivery systems such as liposomes; nanoparticles are proving to be a better option nowadays. As evolution in the drug delivery system, a new system with lesser side effects was introduced in 2011 known as Spanlastics. They are elastic, deformable surfactant-based nanovesicles in which an aqueous solute solution is entirely enclosed. They are shown to be chemically more stable. They provide targeting and controlled release of natural pharmaceutical compounds and have improved several drawbacks of the conventional dosage form. The current review emphasizes the utility of spanlastics, mechanism of penetration, different preparation approaches, their evaluation parameters and applications
A. Sharma, S. Pahwa *, S. Bhati and P. Kudeshia
Lloyd Institute of Management and Technology (Pharm.), Greater Noida, Uttar Pradesh, India.
06 June 2019
01 October 2019
03 February 2020
01 March 2020