SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CLOMIPRAMINE IN BULK AND TABLET DOSAGE FORMAbstract
A simple and sensitive spectrophotometric method has been developed for the determination of Clomipramine in bulk and tablet dosage forms. The method was based on the charge transfer reactions of Clomipramine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone. The absorbance of the highly intensive coloured solution was measured at 470 nm against reagent blank treated similarly. Beer’s law is obeyed in the concentration range of 50-250 μg/ml. Statistical analysis proves that the proposed method is reproducible and selective for the routine analysis of pharmaceutical formulations of Clomipramine.
Aitha Vijaya Lakshmi
Department of Chemistry, Sri Krishnadevaraya University, Kurnool – 518 001, Andhra Pradesh, India
19 December, 2012
19 January, 2013
22 March, 2013
01 April, 2013