SPHERICAL CRYSTALLIZATION OF ZALTOPROFEN FOR ENHANCEMENT OF MICROMERITIC PROPERTIES AND DISSOLUTION RATEAbstract
The present work deals with the spherical crystallization process by Spherical agglomeration method applied to Zaltoprofen, a novel NSAID drug. The object of present study was to prepare and characterize the spherical agglomeration of water insoluble non-steroidal anti-inflammatory drug. Zaltoprofen spherical agglomerates prepared with poly ethylene glycol, which is hydrophilic polymer by using simple spherical agglomeration technique for enhancing micromeritic properties and dissolution rate. The prepared zaltoprofen spherical agglomerates were examined in terms of flow properties, particle size analysis, compression and dissolution behavior. Physical characters of the crystals were studied for the morphology of crystals using scanning electron microscope (SEM), identification of polymorphism done by x-ray powder diffraction (XPRD) and for thermo dynamic properties using differential scanning colorimetry (DSC). The prepared agglomerates were improved the micromeritic properties, packability, wettability, solubility and compaction behavior, as well as dissolution behavior in comparison to pure Zaltoprofen drug.
E. Hari Krishna*, V. Ram Mohan Gupta and S. Jyothi
HOD, Dept. of Pharmaceutics, Shadan College of Pharmacy, Peerancheru, Hyderabad-08, Andhra Pradesh, India
26 February, 2012
19 April, 2012
27 June, 2012
01 July, 2012