STATINS IN POLYCYSTIC OVARY SYNDROMEAbstract
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. PCOS varies from a mild menstrual disorder to severe disturbance of reproductive and metabolic functions. Statins, 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors with intrinsic antioxidant properties, exert profound and broad-reaching effects on various types of tissues. By blocking an early step of the mevalonate pathway, statins inhibit proliferation of several cell types including vascular smooth muscles, hepatocytes, and several neoplastic cell lines. The pleiotropic effects of statins may be due to inhibition of cholesterol synthesis. Some common treatments lifestyle changes, insulin-sensitizing agents.
P. S. Patel*, T. D. Goswami, A. D. Sharma and B. S. Arora
Institute of Clinical Research India Pvt. Ltd., Ahmedabad-380009, Gujarat, India
12 July, 2012
16 August, 2012
17 October, 2012