STATISTICAL ANALYSIS ON EFFECT OF SITAGLIPTIN AND GLIMEPIRIDE ON PANCREATIC BETA-CELLS DURING THE TREATMENT OF TYPE-2 DIABETIC MELLITUSAbstract
The study aimed to analyze the treatment of Sitagliptin with Glimepiride to improve pancreatic beta-cells in T2DM patients. Beta cells are a type of cell found in the pancreatic islet and also synthesize, secrete insulin and amylin. Sitagliptin is found to be maintaining the beta-cells function and glycemic control in T2DM patients. Randomly diabetes mellitus type-2 (T2DM) patients’ data is collected (110 patients) for statistical analysis. For this study, T2DM patients enrolled with the age of 30-60 years, treated with Sitagliptin and Glimepiride once a day. The baseline of HbA1c >7.0% to <10.5%; thus, the performed student t-test is to find out the significant role. The 110 patients are distributed into two groups: one Sitagliptin user group (n=62) and the second Glimepiride user group (n=43). The sitagliptin treatments may also protect also beta cells as the pancreas may not able to regenerate beta-cell.
Praveen Yadav, Bhaskar Joshi and A. Geetha Bhavani *
Department of Chemistry, Noida International University Research Innovation Centre, Noida International University, Gautama Buddha Nagar, Greater Noida, Uttar Pradesh, India.
01 October 2020
09 February 2021
23 June 2021
01 September 2021