STATUS OF GLUCOSE-6- PHOSPHATE DEHYDROGENASE – A RISK FACTOR FOR PREECLAMPSIAAbstract
Background and Objectives: Glucose 6-Phosphate Dehydrogenase (G-6PD) is a ubiquitous enzyme playing a key role in the metabolism of glucose. Reduced activity of G-6PD is one of the most prevalent and genetically determined hereditary defects of the human being. Recently, it has been suggested that reduced G–6PD activity in pre-eclampsia may act as a contributory factor for the development of this complicated pregnancy. Material and Methods: The material for the present study comprised of 50 pregnant females at or after 20 weeks of pregnancy without complications and 50 pregnant women having blood pressure ³ 140/90 mmHg on at least two occasions ³ 4 h apart after 20 weeks of gestation. G-6PD Activity in RBCs was measured. Results: It was found that reduced Glucose-6-phosphate dehydrogenase (G6PD) enzyme activity may be a contributory factor for the development of preeclampsia in pregnancy. Conclusion: Reduced G6PD activity may be one of the causative factors for the development of preeclampsia, so, routine screening of erythrocyte G6PD activity during the antenatal period must be done.
D. Tiwari * and A. Mishra
Department of Biochemistry, Integral Institute of Medical Sciences, Integral University, Lucknow, Uttar Pradesh, India.
01 March 2014
02 June 2014
01 July 2014
01 September 2014