STOMACH SPECIFIC DRUG DELIVERY SYSTEM AND ITS IN VITRO-IN VIVO EVALUATION: A REVIEWAbstract
Stomach specific drug delivery system has occupied importance due to requirement of drug for local action and for those drugs that remains unaffected due to action of gastric fluid. Oral rout is considered most natural, unpredicted, and safe due to its ease of administration, Patient acceptance and convenience. Oral controlled release delivery systems are programmed to deliver the drug in predictable time frame that will increase the efficacy and minimize the adverse effects and increase the bioavailability of drugs. In Stomach specific drug delivery system gastric retention can be achievedby forming bioadhesive system, swelling and expanding system, floating system and high density systems. In fact the buoyant dosage unit enhances gastric residence time (GRT) without affecting the intrinsic rate of emptying and gives prolonged effect of drug. Systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs and reduces dosing time. In this review various types of stomach specific dosage form and their in-vitro and in-vivo parameters for evaluation are discussed.
Sudhir S. Waghmode*, Dhananjay R. Abhang, Manik B. Patil, Nitin A. Gangarde, Dinesh P. Patil and Sachin N. Ahire
K.B.H.S.S.Trust’s Institute of Pharmacy, Bhaygaon road, Malegaon camp, Malegaon, Dist: Nasik– 423 105, Maharashtra, India
09 February, 2012
16 March, 2012
14 May, 2012
01 June, 2012