STRATEGIES FOR ENHANCEMENT OF BIOAVAILABILITY OF MEDICINAL AGENTS WITH NATURAL PRODUCTS

In Advances drug design technologies, a large no of drug molecules are being introduced in every year but many of these molecules have problems like their solubility, stability, bioavailability and its long lasting side effects. Low bioavailability is one of the serious but curable problems in case of the drug molecule. Low bioavailability happens because a lot of molecules unable to permeation the gastrointestinal epithelia. There are some other factors also which responsible for low bioavailability i.e. low lipophilicity and zwitterionic character at physiological pH, poor water solubility or efflux by P-glycoprotein (P-gp) etc. The object of this review is to explore the concept of bioavailability to achieve better therapeutic response in appropriate dose using natural drugs and natural products like ginger, caraway, aloe, quercetin, glycyrrhizin piperine, curcumin etc. The use of natural products is the most reliable means for bioavailability enhancement because these are safe, non-toxic, economical, easily procured, non-addictive, pharmacologically inert and non-allergenic in nature etc. This review explores the natural drugs from plant and animal sources with their mechanism, in-vivo study, marketed formulation and its future prospective