STRUCTURE MODIFICATION OF RITONAVIR WITH CARBAZOLE; SYNTHESIS AND CHARACTERIZATIONAbstract
The core moiety of ritonavir (2S, 3S, 5S)-5-(tert-butyloxycarbonyl)amino-2-amino-3-hydroxy-1,6-diphenylhexane (7) on condensation with oxirane of carbazole (8) in isopropyl alcohol at reflux and deprotected with mineral acid gave compound 10. Coupling of compound 10 with carbamate amino acid (11a-15c) in the presence of EDAC.HCl and HOBt at room temperaturegave ritonavir analogues containing carbazole (16a-20c) as a novel for the human immunodeficiency virus (HIV)-1. These compound were characterized by IR, 1H NMR and Mass spectroscopic.
V. Pandu Ranga Rao*, N. Senthil Kumar , Shankar B. Reddy , Aminul Islam and B. Hari Babu
Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Medak District-502329, Andhra Pradesh, India
07 May, 2013
24 June, 2013
25 August, 2013
01 September, 2013