STUDIES OF DRUG-POLYMER INTERACTIONS OF SIMVASTATIN WITH VARIOUS POLYMERSAbstract
The purpose of the present study is to prepare different combinations of drug Simvastatin (SV) with different polymers like Sodium alginate (SA), Hydroxypropylmethylcellulose (HPMC), Pectin (P), Dillenia (D) and Hydroxy propyl β- cyclodextrin. (HPC), thereby determine and report any possible interactions between the drug Simvastatin (SV) and various polymers both from natural and synthetic sources. The natural plant fruit seed mucilage Dillenia(D) was extracted from the plant Dillenia indica ,Family Dilleniaceae and was dried. Individual polymers and their combinations with drug SV were tested analytically and comparison of the results was done to find out any interactions. The analytical techniques used for the purpose are Fourier Transform Infrared Spectroscopy (FTIR) and Thermogravimetric analysis (TGA). The techniques of FTIR and TGA serves as a good means for determination of any interactions as the change in characteristics of the drug peak and its melting point can be detected by the two techniques respectively. From the study it was Simvastatin when complexed with Hydroxy propyl beta cyclodextrin (HP) showed some changes but these changes were not because of the other polymers used in the combination process.
Trishna Bal* and P. N. Murthy
Assistant Professor, Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
11 October, 2011
09 November, 2011
22 January, 2012