STUDIES ON ANTIDIARRHOEAL ACTIVITY OF LEAVES OF AMORPHOPHALLUS PAEONIIFOLIUS IN EXPERIMENTAL ANIMALSAbstract
Acute diarrhoea is one of the principal causes of death in the infants, particularly in developing countries. An array of medicinal plants with anti-diarrhoeal properties has been widely used by the traditional practitioners; however, the efficacy of many of these anti-diarrhoeal conventional medicines has not been scientifically evaluated. Hence the present study was under taken to explore anti-diarrhoeal activity of Amorphophallus paeoniifolius leaves. Swiss Albino rats of either sex weighing 150-180 g were used for study and anti-diarrhoeal activity was evaluated by castor oil-induced Diarrhoea model. The ethanolic extract of the A. paeoniifolius leaves, at the doses of 100, 200 and 400 mg/kg, reduced the total number of faeces as well as diarrhoeic faeces in a dose dependent manner and the results were statistically significant (p< 0.05). The investigated may be exploited for wide range of diarrhoeal stages and further studies are needed to completely understand the mechanism of anti-diarrhoeal action of A. paeoniifolius leaves.
L. Purwal, V. Shrivastava and U. K. Jain*
Bhopal Institute of Technology & Science-Pharmacy, Bangrasia, Bhopal, Madhya Pradesh, India
18 October, 2010
21 November, 2010
14 January, 2011
01 February, 2011