STUDIES ON ANTIULCER ACTIVITY OF ESSENTIAL OIL OF CALAMINTHA OFFICINALIS MOENCH.Abstract
The present study was undertaken to determine the anti-ulcer potential of Calamintha officinalis Moench, a standardized oil of Calamintha officinalis Moench, commonly known as Calamint. Effect of various doses (0.4ml/kg and 0.8ml/kg,) of Calamintha officinalis Moench. oil was studied on gastric ulcers in pylorus ligation, Diclofenac sodium induced gastric mucosal injury in rats. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total acidity, and pH of gastric fluid. Calamintha officinalis Moench, dose dependently decreased gastric content, total acidity, ulcer index and increased pH of gastric fluid in pylorus ligation ulcer model. In Diclofenac sodium induced ulcer models, all the doses of Calamintha officinalis Moench. oil decreased the ulcer index and increased the pH gastric fluid. These results supported the ethnomedical uses of oil of Calamintha officinalis Moench. in the treatment of gastric ulcer.
Mohini Verma*, R. Irchhaiya, P. P. Singh, Deepak Kailasiya and Vinod Kanaujia
Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India
28 July, 2011
21 September, 2011
28 September, 2011
01 October, 2011