STUDIES ON FORMULATION AND EVALUATION OF IBUPROFEN MATRIX DRUG DELIVERY SYSTEM BY USING “BEE PROPOLIS” (APIS MELLIFERA L.)

Ibuprofen is a Non-steroidal anti-inflammatory (NSAID) class drug and is used to treat pain, minor aches, fever, inflammation, and arthritis. Ibuprofen has an oral dose of 300 mg minimum and 3200 mg maximum in a day and is the main reason for the increase in its dosing frequency; many of the Ibuprofen formulations are of three times a day dosing and is the main reason for the development of such a formulation which can reduce the dosing frequency, so many researchers developed Ibuprofen matrix dosage form which can give a prolonged therapeutic effect. But in this formulation, Ibuprofen is combined with a Natural, Resinous substance known as “Bee Propolis” or simply “Propolis” Propolis is a natural substance collected by some species of Honey bees; it is a resinous, gummy material that has many therapeutic properties and can also be used as a natural binder in the dosage form due to its good binding abilities and, it can also give a positive synergistic effect when combined with Ibuprofen. In this study, the formulation was developed as a matrix dosage system in an oral tablet form with a dose of 400 mg/ tablet. Though not all honey bee species are capable of making propolis some of the honey bee species, such as “Apis mellifera L.”, “Apis Dorsata”, etc. in India are capable of making Propolis. Propolis has 350-500 chemical constituents which can be used in many therapeutic activities; such chemical constituents present in a single product makes it more valuable in further research.