STUDIES ON POLYMORPHISM OF COMMERCIAL ASPIRIN AND ALBENDAZOLE TABLETSAbstract
Aspirin is a common medication used to treat pain, fever and inflammation. It shows the property of polymorphism and two polymorphic forms were characterized till now (Form I and Form II). Albendazole is another common medication used for the treatment of variety of parasitic worm infestations. This drug also shows polymorphism where two forms (Form I and Form II) of it were characterized till date. Various commercial aspirin and albendazole tablets were collected, powdered and after proper clean up procedure their melting points were determined to identify the polymorphic form of each drug sample. The detection of polymorphic form was further carried out by infra red spectral analysis. It was found that all the commercial aspirin samples under study belong to the polymorphic form II which is usually used in drug formulation. Polymorphic studies on commercial albendazole tablets showed that all the samples under investigation belong to the polymorphic form I which is commonly marketed.