STUDIES ON THE DISINTEGRANT PROPERTIES OF SEED POWDER, HUSK POWDER AND MUCILAGE OF PLANTAGO OVATA BY FORMULATION OF ORALLY DISINTEGRATING TABLETAbstract
Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegrating tablets are intended to dissolve or disintegrate rapidly in the mouth for which various natural and synthetic disintegrants are included in the formulation. The present work emphasis on the study of disintegrant property of mucilage, Husk powder and seed powder of Isapghula. The Orally disintegrating tablet of Fexofenadine HCl (as model drug) was prepared by direct compression method using microcrystalline cellulose and Mannitol as direct compressible vehicle. These tablets were evaluated for quality control tests like organoleptic characteristics, weight variation, hardness, friability, in-vitro disintegration time, in-vitro swelling time, drug content and dissolution behavior. Swelling index was also investigated with an aim to compare the swelling property of seed powder, husk powder and mucilage of Plantago ovata. Among all the superdisintegrants, Plantago ovata mucilage showed the highest swelling index. Hence, the present study revealed that this natural superdisintegrant (Plantago ovata mucilage) showed similar disintegrating property than the most widely used synthetic superdisintegrants in the formulations of ODT.
Mahaveer Pr. Khinchi*, M. K. Gupta , Anil Bhandari , Dilip Agarwal and Natasha Sharma
Department of Pharmaceutics, Kota College of Pharmacy, Ranpur, Kota, Rajasthan, India
11 August, 2010
12 November, 2010
26 December, 2010
01 January, 2011