STUDIES ON THE SYNTHESIS AND IN-VITRO ANTIMICROBIAL ACTIVITY EVALUATION OF SOME NOVEL β-LACTAMS CONTAINING SULFA DRUGS
AbstractThe present study aims to synthesize 2-azetidinone derivatives; 4-(3-chloro-1-(4-substituted-phenyl)-4-oxoazetidin-2-yl)-2-methoxyphenyl-acetate (c1-c6) and 2-allyl-4-(3-chloro-1-(4-Substituted-phenyl)-4-oxoazetidin-2-yl)-6-methoxyphenyl4-methylbenzenesulfonate (d1-d6) by electrocyclisation of imines with chloroacetylchloride in the presence of triethyle – amine and 1, 4-dioxane. The synthesized compounds were characterized by FT-IR, 1H NMR spectra and elemental analysis and were screened in-vitro against three bacterial strains namely Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and two fungal strains namely Aspergillus niger, Aspergillus flavus by disc diffusion method. The compounds exhibited good antimicrobial activity.
Article Information
29
3446-3451
503
1024
English
IJPSR
P. Deshmukh, P. K. Soni*, M. K. Ahirwar and A. K. Halve
School of Studies in Chemistry, Jiwaji University, Gwalior, Madhya Pradesh, India
pradeepsonij@gmail.com
02 January, 2017
12 July, 2017
19 July, 2017
10.13040/IJPSR.0975-8232.8(8).3446-51
01 August, 2017
Download