STUDY OF ANTHELMINTIC AND INSECTICIDAL ACTIVITIES OF DIFFERENT EXTRACTS OF KAEMPFERIA GALANGAAbstract
Kaempferia galanga has profound implications in the treatment of nematocide, larvicide, abdominal discomfort, cholera, various inflammatory diseases and many more. It is a potential candidate in terms of evaluating its medicinal activities. Therefore, the present study was conducted to evaluate anthelmintic and insecticidal activities of different extracts of the rhizome of Kaempferia galanga. For anthelmintic activity, Pheretima posthuma was selected as test animal while 25, 50, 100 mg/ml concentrations of samples were tested in the bioassay, from which time of paralysis and time of death of worms were estimated. Evaluation of insecticidal activity was performed against Sitophilus oryzae to calculate the mortality rate. In anthelmintic study, extracts exhibited its activity in dose-dependent manner showing higher the concentration, higher the effect. Extracts of ACR, PEF, CHF and MEF in case of 100 mg/ml concentration exhibited its paralytic effect followed by death within a short period of time among which ACR extract gave the best result which only took approx. 20 mins to show paralytic effect and 35 min for death sentence. In insecticidal activity, all extracts showed potent activity with 100% mortality of rice insects Sitophilus oryzae at 80 mg/ml concentration in 24hrs, proving the activity also followed dose dependent pattern. 90% mortality rate observed in case of 80 mg/ml concentration of MEF extract in 12 hr whereas ACR and CHF extracts showed 70 % and PEF showed 50% mortality rate in treated rice insects. The present study shows that all the extracts of Kaempferia galanga are found to possess anthelmintic and insecticidal activities.
P. R. Dash *, K. M. Mou, I. N. Erina, F. A. Ripa, K. N. Al Masud and Md. Shawkat Ali
Department of Pharmacy 1, BRAC University, Mohakhali, Dhaka, Bangladesh
28 July, 2016
12 September, 2016
26 September, 2016
01 February, 2017