STUDY OF CYCLOOXYGENASE-3 ON THE BASES OF ITS FACTS AND CONTROVERSIESAbstract
Prostaglandin endoperoxide synthases, usually known as cyclooxygenases (cyclooxygenase-1 and cyclooxygenase-2), catalyze a key step in the formation of biologically effective prostaglandins. In recent times, a cyclooxygenase-1 variant protein, called cyclooxygenase-3 used to be found and characterized. COX-3 is studied recent along with significant margin for the formation of anti-inflammatory, analgesic and anticancer agents. In a pharmaceutical area, various drugs targeted on this enzyme are Acetaminophen, Dipyrone, Antipyrine, Dimethylaminopyrene, Diclofenac, Aspirin, Ibuprofen, Thalidomide and Caffeine. It is a new era for COX family that contains numerous significant applications that’s the reason it is the center of attraction for researchers. Currently, the role of COX-3 in human is unclear, but scientists continue to do work in this area. The objectives of this review article are to gather all newest data literature related to developments in the structural and biochemical features of the cyclooxygenase-3 isoenzyme along with discussing its application for the various pharmacological effects of drugs.
S. Sharma *, A. Verma, R. Chauhan, M. Kedar and R. Kulshrestha
Department of Pharmacy, Banasthali University, Banasthali, Rajasthan, India.
01 May 2018
26 June 2018
02 July 2018
01 January 2019