STUDY OF DIFFERENT PROCESSING PARAMETERS FOR POLYLACTIC ACID MICROSPHERES FORMULATIONSAbstract
To evaluate the effects of different processing parameters on drug-loaded microspheres, the solvent evaporation technique was chosen as the formulation method. Indomethacin-loaded Polylactic acid microspheres were prepared by varying drug masses, then by changing the stirring speed. They were analyzed for their drug content, physical morphology, size, polymer-drug physicochemical compatibility, and in-vitro drug release. Microspheres revealed a spherical profile along with a porous structure. The effect of changing the drug mass was noted on drug encapsulation and loading efficiencies. Indomethacin had better encapsulation when introduced in small amounts. On the other hand, the effect of changing the stirring speed was remarkable on the size of obtained microspheres and drug release profile. The particle size decreased as the speed of mixing increased. Also, a faster drug release was observed for larger microspheres.
D. Moussa, R. Kassab * and P. Yammine
Department of Chemistry, Faculty of Sciences, University of Balamand, Tripoli, Lebanon.
20 March 2014
05 June 2014
09 July 2014
01 October 2014