STUDY OF MEDICINAL PLANTS USED IN THE MANAGEMENT OF CARDIOVASCULAR DISEASES AT LIBREVILLE (GABON): AN ETHNOPHARMACOLOGICAL APPROACHAbstract
This work was conducted at a Libreville herbal market located in Peyrie in order to inventory plants used by people for the management of cardiovascular diseases such as hypertension and to evaluate their pharmacological effects. The method of preparation and modes of administration were also recorded. Twenty nine herbalists were interviewed using questionnaires. Twenty two plant species belonging to sixteen families and seventeen recipes were identified. The commonly used plants were Guibourtia tessmannii, Musanga ceropioiodes, Senecio gabonensis. Among them, G. tessmannii appeared to be the most used plant species. Phytochemical studies on extracts of G. tessmannii revealed the presence of alkaloids, sugars, polyphenols, sterols, tannins and saponosids. Pharmacological studies performed in the isolated aorta of rats showed a vasorelaxant effect on adrenalin- or KCl- induced contraction. G Tessmannii-induced vasorelaxation was significantly but not totally reduced by endothelium removal or by a pretreatment with L-NAME, suggesting the involvement of endothelium-dependent and -independent mechanisms. Medicinal plants and G. tessmannii in particular may represent a sourceofefficientantihypertensive agents.
N.O. Koumba Madingou , A. Souza*, M. Lamidi , L.E. Mengome , C. Eyele Mve Mba , Bading Bayissi , J. Mavoungou , A.S. Traore
Laboratoire de Physiologie Animale et de pharmacologie, Unité de Recherche d’Agrobiologie, Université des Sciences et Techniques de Masuku, BP: 943, Franceville Gabon
23 August, 2011
18 October, 2011
27 December, 2011