STUDY OF PHYTO CHEMICAL, ANALGESIC AND ANTI ULCER ACTIVITY OF EXTRACTS OF AERIAL PARTS OF CARDIOSPERMUM HALICACABUM LINN.Abstract
The dried aerial parts of Cardiospermum halicacabum Linn were subjected to extraction using the solvents (petroleum ether, chloroform, Ethyl acetate and ethanol) in increasing order of polarity. The prepared extracts were then subjected to preliminary phytochemical analysis. It was found plant possesses carbohydrates, alkaloids, sterols, flavanoids and saponins. All extracts were selected for further study. The analgesic activity of all extracts of aerial parts was assessed in albino mice using thermal stimulus model. morphine and Paracetamol were used as standard. The results indicate that, petroleum ether extract showed 34% (0.15mg/ml) and 58 %( 0.3mg/ml) significant activity, when compared with morphine. Comparison with Paracetamol the pet ether extract showed 48% (0.3mg/ml) and 82% (0.3mg/ml) significant activity. The ulcer activity was determined by pylorus ligation technique. Ranitidine (50mg/kg) used as standard. The ethanol extract showed 48.2% (18.75mg/2ml) significant antiulcer activity compared with standard drug. From the present study it may be concluded that the constituents present in all the extracts may be responsible for both activities.
P. Muthumani*, R. Meera, S. Venkatraman, Sundara Ganapathy and P. Devi
Department of Pharmaceutical Chemistry, K M College of Pharmacy, Uthangudi, Madurai, Tamil Nadu, India
23 May, 2010
17 August, 2010
17 September, 2010
01 October, 2010