STUDY OF POTENTIAL TO INHIBIT HEMOZOIN FORMATION OF SOME NOVEL AMINOPROPANOLSAbstract
One of the factors responsible for malaria pathogenesis is the suppression of host immune responses. This suppression enhances parasitemia and diminishes the host immune response to malaria-expressed proteins and other pathogens. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the design of new therapeutic products against malaria. In the present research, some novel compounds are synthesized and targeted against hemozoin growth. The consideration of new chemotherapeutic targets in malaria research is most likely to identify new classes of drugs. The present work deals with the synthesis of a small library of 2-alkoxy/phenoxy-3-amino-3-arylpropan-1-ols by reductive ring opening of the corresponding azetidine-2-ones. After characterization of synthesized compounds, these were evaluated for hemozoin formation inhibition assay. The results showed that all compounds are inhibiting hemozoin formation comparable to Clotrimazole. This may be concluded that the synthesized compounds exhibit antimalarial activity via inhibition of hemozoin formation.
Priya Jain * and D. S. Bele
Pacific Academy of Higher Education and Research Society, Udaipur, Rajasthan, India.
30 November, 2016
31 January, 2017
17 February, 2017
01 June, 2017