STUDY OF VARIATION IN ELECTROCHEMICAL BEHAVIOUR OF FURAZOLIDONE AND METRONIDAZOLE SIMULTANEOUSLY BY DIFFERENTIAL PULSE VOLTAMMETRYAbstract
In present study, a successful attempt has been made to study the variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously using Differential Pulse Voltammetry (DPV) technique. The effect of different pH (2-10) of Britton-Robinson Buffer on voltammogram using 1M KCl as a supporting electrolyte was studied. The optimum pH was found to be pH 4.25. Both Furazolidone and Metronidazole exhibited reduction cathodic peak at optimum pH with peak potential at -0.06 V for Furazolidone, and -0.22 V for Metronidazole vs. S.C.E. 0.1N CH3COOH was used as Solvent for the analysis. The variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously at the optimized pH was studied by varying pulse amplitude and scan rate. The optimized pulse amplitude was found to be 50 mV, and the optimized scan rate was found to be 15 mV/s. This study can be used developing methods for simultaneous detection and quantification of Furazolidone and Metronidazole.