STUDY ON DETECTION METHODS FOR URIC ACID IN BIOLOGICAL SAMPLESAbstract
Uric acid is the end-product of purine metabolism and a major antioxidant in humans. Most of the uric acid produced from the catabolism is readsorbed into the blood circulation system after primary filtration and partial secretion by the kidney. Uric acid levels in physiological fluids such as plasma and urine serve as valuable indicators for certain clinical conditions. An elevated uric acid in urine or serum can affect renal function and blood pressure, which is an indicator of gout, cardiovascular and renal diseases, hypertension, etc. Low uric acid levels may be associated with molybdenum deficiency, copper toxicity and worsening of multiple sclerosis. Therefore, detection of uric acid level dissolved in human physiological fluids is indispensable for diagnosis of patients suffering from these disorders associated with altered purine biosynthesis and catabolism. In this article the studies of detection methods for uric acid in biological samples in recent years are reviewed.