SUB-CHRONIC TOXICOLOGICAL INVESTIGATION OF GMELINA ARBOREA (VERBENACEAE) IN HEALTHY WISTAR RATS
AbstractThe study was designed to determine the acute and sub-chronic toxic effects of aqueous extract of Gmelina arborea (Roxb.) in healthy male Wistar rats. An aqueous bark extract of G. arborea was administered at graded doses (0.25-2.00 g/kg) to Wistar rats in the acute toxicity test. Sub-chronic toxicity was evaluated by daily administration of the extract at 1.00 g/kg to Wistar rats for 30 days. All animals were physically active and no death was observed up to the dose of 2.00 g/kg in the acute toxicity study. The hematological parameters, serum concentration of liver enzymes and relative organ weight did not differ significantly in treated rats as compared to untreated healthy rats (P > 0.05). The histopathological study revealed no treatment-related gross cellular changes in vital organs in treated rats. The administration of the bark extract of G. arborea (1.00 g/kg) was found to be toxicologically safe in Wistar rats
Article Information
8
4549-4554
481KB
1317
English
IJPSR
A. P. Attanayake*, K.A.P.W. Jayatilaka , C. Pathirana and L.K.B. Mudduwa
B. Sc. (Hons), Lecturer, Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Sri Lanka
anojaattanayake@yahoo.com
21 July, 2013
21 September, 2013
17 November, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4549-54
01 December 2013
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