SUITABILITY OF DIFFERENT GRADES OF GELUCIRE AND PEG-6000 FOR SOLUBILITY ENHANCEMENT OF TINIDAZOLE BY PROCESS OF SOLID DISPERSIONAbstract
Tinidazole is a synthetic antiprotozoal and antibacterial agent which is practically insoluble in water.Oral dose of tinidazole is very high (2gm) owing to its limited solubility. Present research focuses on enhancement of solubility of tinidazole using the technique of solid dispersion which is reported to be one of the simple technique for solubility enhancement using various grades of Gelucire and PEG 6000. The ratio of drug and Carrier was decided based on phase solubility study. Solid dispersions were prepared by different techniques such as physical mixture, kneading, co-precipitation and closed melting method.Compatability between drug and carrier was checked by FTIR studies. Efficiency of solid dispersions was checked by conducting saturation solubility testing in water. Multimedia dissolution was carried in different media’s such as Water, 0.1 N HCl and Phosphate Buffer after checking drug content. The formulations were found to enhanced solubility and dissolution as compared to pure drug.
Ajay Sahoo and Shilpa Bhilegaonkar *
PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa , India
30 July, 2014
28 November, 2014
27 December, 2014
01 April, 2015