SYNERGISTIC EFFECT OF AZADIRACHTA INDICA AND CURCUMA LONGA WITH FLUCONAZOLE GEL AGAINST CANDIDA ALBICANSAbstract
In this study, the synergistic effect of an extract of Azadirachta indica and Curcuma longa were investigated by the agar diffusion method. Different dilutions of the extract were prepared, and antifungal activity of the extracts of Azadirachta indica and Curcuma longa against Candida albicans was measured alone and in combination with fluconazole gel. The zone of inhibition of Azadirachta indica and Curcuma longa was found to be 9 mm to 14 mm and 8 mm to 13 mm respectively in the concentration range of 10-60 µL against Candida albicans. The fluconazole gel was prepared, and various evaluation parameters like; spreadability, pH, viscosity, and drug content were determined. Extracts of Azadirachta indica and Curcuma longa were taken in different strength (10-60 mg/ml) however the concentration of fluconazole gel was kept constant (1%) and zone of inhibition was determined. The maximum zone of inhibition was found with Azadirachta indica in the combination of 60mg/ml and Curcuma longa 20 mg/ml.
A. Saini, G. Saini, B. Singh *, M. Vyas, S. Verma and O. Prakash
Department of Quality Assurance, Abhilashi College of Pharmacy, Mandi, Himachal Pradesh, India.
08 June 2018
11 September 2018
26 November 2018
01 February, 2019