SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME COMPOUNDS OF 1,8-NAPHTHYRIDINE-3-CARBOXAMIDEAbstract
Various nitrogenous heterocyclic compounds like 1, 8-naphthyridine-3-carboxamide are synthesized and studied for their wide range of biological activity. Versatile activity of this scaffold will increase interest from innovator on significance of their antibacterial activity and will influence their role in drug discovery. Synthesis and Antibacterial evaluation of ten derivatives of 1-ethyl-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxamide (SD-1 – SD-10) is discussed in this paper. Synthesis of novel 1, 8-naphthyridine-3-carboxamide derivatives starting from substituted pyridine with ethoxy-methylenemalonate ester by cyclo-condensation reaction affords 1,8-Napthyridine-3-carboxylate at high temperature and at specific reaction condition. All 1, 8-napthyridine-3-carboxylate compounds were treated with an excess of substituted aniline with mild reaction conditions. All the compounds obtained were purified by using the recrystallization method. Structure confirmation of synthesized compounds was accomplished on the basis of IR, 1H NMR, and MS. The synthesized compounds were tested against bacterial strain, Escherichia coli (Gram-negative) Staphylococcus aureus (Gram-positive). Many of the compounds exhibited significant antibacterial profile.
M. R. Suryawanshi * and D. D. Dupade
Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Earandwane, Pune, Maharashtra, India.
26 June 2019
18 January 2020
02 April 2020
01 May 2020