SYNTHESIS AND ANTIDIABETIC EVALUATION OF SOME THIAZOLIDINE-2, 4-DIONE DERIVATIVESAbstract
Condensation of thiaourea with chloro acetic acid gave Thiazolidinedione which react with aromatic aldehyde and produce 5- benzylidine, 2, 4 Thiazolidinedione.To this different secondary amine was reacted and final derivatives was obtained. The structures of these compounds were established by means of IR, 1 H-NMR.All the compounds were evaluated for antidiabetic activities. Most of the compounds have shown significant antidiabetic activity when compared with the standard drug.
ASHUTOSH MISHRA, GAUTAM V.*, GHANSHYAM, BANDANA SINGH, SWEEMIT J., SAROJ KUMAR
A.N.D College of Pharmacy*, Bhabhnan, Gonda, (U.P.), India
4 December, 2009
23 January, 2010
27 January, 2010
01 February, 2010