SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 2- AMINOTHIAZOLE DERIVATIVESAbstract
Novel 2- Aminothiazole derivatives were synthesized by the reaction of 2-aminothiazole (1) with chloroacetylchloride in presence of K2CO3 in chloroform afforded 2- chloro- N- (thiazol – 2- yl) acetamide (2). Compound (2) on condensation with substituted phenols in presence of K2CO3 in acetone afforded the title compound (3a-g). The chemical structures of the synthesized compounds were elucidated on the basis of IR, 1H NMR data. The synthesized compounds were screened for antibacterial and antifungal activity among them the compound 3c and 3d have shown significant inhibition of bacterial and fungal growth.
Sushil Kumar*, Ramesh Kumar Singh, Pragati Varshney, Shruti Varshney and Avinash Kumar Mishra
Drug Design & Medicinal Chemistry Research Laboratory, College of Pharmacy, IFTM, Moradabad, (UP) India
01 April, 2010
23 June, 2010
10 July, 2010
01 August, 2010