SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 3, 4- DIHYDROPYRIMIDINONESAbstract
A number of aldehydes were reacted with acetyl acetone or ethyl acetoacetate and urea under Biginelli reaction conditions to give the corresponding 5-acyl-4-(substituted-aryl)-6-methyl-3,4-dihydropyrimidin-2-one. The 5-acetyl-derivatives were converted into pyrimido-oxazoles, pyrimido-pyrazoles, and chalcones. Some Mannich bases were also synthesized. Some selected compounds were tested for their antimicrobial activitites.
Wageeh S. El-Hamouly*, Kamelia M. Amine , Hanaa A. Tawfik Dina H. Dawood and Mausa Elsayed Moharam
Department of Chemistry of Natural Products, National Research Centre, Dokki, Giza, Egypt
08 January, 2011
20 March, 2011
24 March, 2011
01 April, 2011