SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME QUINOLINE DERIVATIVESAbstract
Cyclocondensation of 5-6 and 7-8 with chloroacetyl chloride in presence of triethylamine give 9-10 and 11-12 respectively. All the synthesized compounds 1-12 have been screened for their antibacterial as well as antifungal activities and compared with reference drugs streptomycin and fusidic acid respectively. These synthesized compounds were screened for their antibacterial activity against S. aureus and B. subtillis and antifungal activity against A. niger and C. albicans. The melting points were determined in open glass capillaries tubes. Purity of the compounds was checked by thin layer chromatography (TLC) on silica gel G plates and spots were located by using iodine chamber. All the newly synthesized compounds were confirmed by elemental (C, H, N) and spectral IR, 1HNMR analysis. In this series compound 10 showed better antibacterial activity than reference drug streptomycin and compounds 10 and 12 were found to be more potent antifungal agents than reference drug fusidic acid.