SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-(2-(BENZO [D] OXAZOL-2-YL) PHENYLAMINO)-N-(SUBSTITUTED PHENYL) ACETAMIDESAbstract
In the present work six new benzoxazole derivatives were synthesized adopting the suitably selected scheme. The synthetic methodology included the synthesis of 2-(2-aminophenyl) benzoxazole (D1) by the reaction of anthranilic acid with 2-aminophenol in poly phosphoric acid. Substituted chloroacetanilides (A1-A6) were synthesized by the reaction of substituted anilines with chloroacetyl chloride. Finally compound 2-(2-(benzo[d]oxazol-2-yl) phenylamino)-N-(substituted phenyl) acetamide (2A-2F) were synthesized by the fusion of 2-(2-aminophenyl) benzoxazole (D1) and substituted chloroacetanilides (A1-A6). All the aynthesized compounds were subjected to antimicrobial screening against the bacterial strains i.e., Bacillus subtilis (MTCC-619), Streptococcus pneumonia (recultured), Escherichia coli (NCTC 6571) and Staphylococcus aureus (NCTC 7447). The compounds were also tested for antifungal potential against two fungal strains i.e. Aspergilus. Niger (NCIM NO. 618) and Candida albicans (NCYC 597). In all the testing a significant correlation existed between the antimicrobial potential and the concentration of test compound.
Priyanka*, N.K. Sharma, K. K. Jha and M. Vijaya Kumar
Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Bagarpur, Moradabad, Uttar Pradesh, India
05 February, 2014
10 April, 2014
30 May, 2014
01 August, 2014