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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF CHROMONES BEARING 1, 5-BENZO THIAZEPINYL MOIETY

Abstract

1, 5-Benzothazepinyl chromones were synthesized starting from 2, 4-diacyl phenol. The 2, 4-diacyl phenol was condensed with aryl aldehydes to obtain bis-chalcones1a-d. The bis-chalcones on cyclocondensation with equimolar amount of 2-aminothiophenol gave 1, 5-benzothiazepinyl chalcones2a-d. The chalcones on oxidative cyclisation in DMSO – I2 yielded the titled compounds3a-d. The microbial evaluation of the representative 1, 5-benzothiazepinyl chromones has also been performed.

Article Information

35

1495-1498

302KB

1181

4

English

IJPSR

R.V. Dengle*and R. N. Deshmukh

Associate Professor, Department of Chemistry, Vivekanand College, Kolhapur – 416002, Maharashtra, India

drrameshdengle@gmail.com

30 December, 2012

21 February, 2013

15 March, 2013

http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1495-98

01 April, 2013

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