SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME SUBSTITUTED 2, 3-SUBSTITUTED QUINAZOLINONE ANALOGS
AbstractIn recent years, there is a tremendous increase of drug resistant pathogens, leading to the design and development of newer antitubercular agents. A series of 2-(substituted-phenyl)-1,3-benzoxazin-4-ones and 3-amino-2-(substituted-phenyl)quinazolin-4(3H)-ones were synthesized by the reaction of substituted benzoyl chloride with anthranilic acid and 2- (substituted phenyl)-1,3-benzoxazin-4-one with hydrazine hydrate in absolute alcohol respectively. The title compounds 2-substituted phenyl-3-(thiophen-2-ylmethyleneamino) quinazolin-4(3H)-ones and 2-(substituted phenyl)-3-(1-(furan-2-yl)ethylideneamino) quinazolin-4(3H)-ones were obtained by reacting 3-amino-2-(substituted phenyl) quinazolin-4(3H)-one with thiophene-2-carboxaldehyde and 2-acetyl furan respectively. The title compounds have been characterized by UV, IR, 1H-NMR and Mass spectra. The synthesized compounds have been evaluated for their antitubercular activity. Few of the compounds exhibited significant antitubercular while other compounds showed moderate activity
Article Information
49
4394-4397
630KB
1266
English
Ijpsr
S. Rajasekaran*, Gopalkrishna Rao , H.S. Niranjan
Assistant Professor, Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore-560 027, Karnataka, India
rajasekaranpharm@gmail.com
21 July, 2012
17 October, 2012
31 October, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(11).4394-97
01 November,2012
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