SYNTHESIS AND BIOCIDAL ACTIVITY OF Co (II) AND Zn (II) COMPLEXES OF SULFA DRUG SCHIFF BASESAbstract
The novel Co (II) and Zn (II) complexes have been synthesized by reaction of CoCl2/ZnCl2 with Schiff bases of benzoyl derivative of 3-methyl-1-phenyl-2-pyrazoline-5-one and sulfa drugs in 1:2 ratio. The synthesized complexes were screened/tested for their antimicrobial activity against pathogenic bacterial strains i.e. E. coli, Staphylococcus aureus strain I, Staphylococcus aureus strain II, Staphylococcus aureus strain III, Vibrio cholera, Gram positive Cocci, Gram positive Bacillus, Gram negative Bacillus, Bacillus subtilis and Salmonella typhimurium. It was found that metal complexes have more antimicrobial activity than their parent Schiff bases. Complexes of Schiff base ligand sulfamerazine and bmphp (L2) were also found to be more active.
S. Roy* and A. D’souza
Department of Chemistry and Biochemistry, St. Aloysius’ (Autonomous) College, 1 Ahilya Bai Marg, Pentinaka Chowk, Sadar, Jabalpur, Madhya Pradesh- 482001, India
24 April, 2014
23 June, 2014
, 19 July, 2014
01 November, 2014